| Cocaine prevents the reabsorption of dopamine in the brain’s reward areas. After you use enough blow, your brain reduces the number of dopamine receptors in this region, figuring it's already got plenty of it. You can see where this is going. Because there are now fewer receptors, stopping the drug makes you crave it—after all, the body needs its dopamine. Cocaine doesn’t destroy dopamine neurons like methamphetamine, which makes its effect less powerfully addictive, but the fast method of use (snorting), short high (less than an hour) and rapid tolerance put it in the top ten. |
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